ICD-10-CM Diagnosis Code A06.81: Amebic cystitis

A06.81 is a billable and specific ICD-10-CM code. Accurate documentation of A06.81 facilitates proper diagnosis, effective management, and correct reimbursement.

This guideline will provide the use, official coding guidelines, and historical background of A06.81.

What is the ICD-10-CM Diagnosis Code for Amebic cystitis?

The ICD-10-CM diagnosis code for Amebic cystitis is A06.81.

Amebic cystitis is a rare urinary tract infection caused by Entamoeba histolytica, where the parasite invades the bladder, leading to inflammation.

Symptoms may include painful urination, blood in urine, and lower abdominal discomfort. Diagnosis involves urine analysis, imaging, or PCR tests, and treatment includes anti-amebic medications like metronidazole.

Proper documentation using A06.81 ensures patients receive appropriate care and enables accurate healthcare reimbursement.

History Background of ICD-10-CM Diagnosis Code A06.81

The ICD-9-CM system, first introduced in 1979, provided the initial framework for coding diseases and health-related conditions in the United States.

There is no specific ICD-9-CM code for Amebic cystitis. Instead, it falls under ICD-9-CM Code 006.8 (Amebiasis at other sites), which includes all extraintestinal amebic infections, such as those affecting the bladder, kidneys, or other organs outside the intestines.

For a more detailed diagnosis, doctors may use ICD-9-CM Code 595.4 (Chronic interstitial cystitis) along with 006.8 to specify bladder inflammation due to amebiasis.This coding remained consistent from 1979 to 2015.

While the ICD-9-CM system offered a basic approach to disease classification, modern healthcare needs more detail and specificity.

To address this, the ICD-10-CM system was launched in 2015, introducing a more comprehensive and accurate coding structure.

The transition from ICD-9-CM to ICD-10-CM significantly improved the ability to document and analyze conditions such as Amebic cystitis.

The 2025 edition of ICD-10-CM A06.81 became effective on October 1, 2024.

Year	ICD-10-CM Code	Description
2020	A06.81	No Change
2021	A06.81	No Change
2022	A06.81	No Change
2023	A06.81	No Change
2024	A06.81	No Change
2025	A06.81	No Change

Other ICD-10-CM Diagnosis Codes in A06

ICD-10-CM code A06 | Amebiasis has following sub categories including A06.81 :

A06.0 Acute amebic dysentery.
A06.1 Chronic intestinal amebiasis.
A06.2 Amebic nondysenteric colitis.
A06.3 Ameboma of intestine.
A06.4 Amebic liver abscess.
A06.5 Amebic lung abscess.
A06.6 Amebic brain abscess.
A06.7 Cutaneous amebiasis.
A06.8 Amebic infection of other sites.
A06.81 Amebic cystitis.
A06.82 Other amebic genitourinary infections.
A06.89 Other amebic infections.
A06.9 Amebiasis, unspecified.

Final Thought

Proper coding of A06.81 is essential for diagnosing and managing Amebic cystitis. A clear understanding of its History, and correct usage enhances medical documentation and ensures effective treatment, patient care, supports healthcare planning, and guarantees proper reimbursement for medical services.

Dr. Sehrish Bano, CPB & CPC

As a certified professional in both billing and coding, I specialize in streamlining healthcare revenue cycles and ensuring accurate claim submissions. With more than five years of experience serving the healthcare industry in the USA, I bring expertise in coding accuracy, compliance, and reimbursement optimization. My work focuses on reducing errors, improving efficiency, and supporting providers in delivering quality care without administrative hurdles. I am committed to helping healthcare organizations achieve financial stability and compliance through reliable billing and coding practices.